New Research

Weight loss medications are all the rage today.  They are usually given by injection and have side effects including a rare form of blindness.  Not surprisingly, all have the caveat that the treatment must be accompanied by diet and exercise.

I am exploring a safe and effective while inexpensive means of rendering the same health benefit; lowering blood sugar and weight loss.

I have been studying a food substance protocatechuic acid (PCA) for near 20 years.  I have multiple US patents related to its various health benefits.

It is possible that protocatechuic acid taken as a food supplement may have a role in control of type II diabetes and/or weight loss.

There is a basis for this in that it is in the literature that polyphenols in general may have a role in treatment of type II diabetes and weight loss.  Protocatechuic acid is chemically a polyphenol.

Wang, Y.; Alkhalidy, H.; Liu, D. The Emerging Role of Polyphenols in the Management of Type 2 Diabetes. Molecules 2021, 26, 703.

Cremonini E, Daveri E, Mastaloudis A, Oteiza PI. (-)-Epicatechin and Anthocyanins Modulate GLP-1 Metabolism: Evidence from C57BL/6J Mice and GLUTag Cells. J Nutr. 2021 Jun 1;151(6):1497-1506. doi: 10.1093/jn/nxab029. PMID: 33693759; PMCID: PMC8659349.

Massimo D’Archivio, Beatrice Scazzocchio, Annalisa Silenzi, Claudio Giovannini, Roberta Masella,  Chapter 14 – Role of Protocatechuic Acid in Obesity-Related Pathologies: An Update,

Editor(s): Ronald Ross Watson, Victor R. Preedy, Sherma Zibadi,

Polyphenols: Mechanisms of Action in Human Health and Disease (Second Edition),

Academic Press,  2018,  Pages 181-192,  ISBN 9780128130063,


Therefore, I have launched a randomized double blinded controlled human study to confirm or refute what is in the literature and explore the potential new health benefits to taking daily PCA.

We are asking the question of what effect will dose related oral PCA have on the human blood clotting, blood glucose, body weight, and biomarkers for immunity (CXLX9) and weight control protein glucagon-like peptide 1 (GLP-1)*.

* Glucagon-like peptide 1 (GLP-1) is a hormone made in the small intestine usually following eating.  GLP-1 is a 30 amino acid peptide that has the following effects.

  • Increases insulin release from the pancreas which decreases blood sugar.
  • Blocks the glucagon hormone which effect otherwise would raise your blood sugar.  GLP-1 prevents glucose entering the blood stream.
  • Slows the stomach emptying which therefore slows down the release of sugar into the blood stream.
  • Gives a sense of satisfaction that one is full after eating.  This is called a satiety factor.