10/12/2017: I learned that my application U.S. Application No. 15/189,510 Title: “ANTIMICROBIALS AND METHODS OF USE THEREOF”
resulted in successfully granted the following claims which I have proof that after cosmetic skin defoliation or dermabrasion that the wound healing will be enhanced showing rapid healing, minimal inflammation and importantly restoration of the skin collagen layer. This has the potential for wrinkle treatment in combination with skin defoliation and/or dermabrasion.
Allowed Claims
1–32. (Cancelled)
- A method of treating a wound to promote healing consisting essentially of administering a composition of an aqueous solution comprising 2,4,6,trihydroxybenzaldehyde (“246 THBA”) and protocatechuic acid (PCA) both of which are present at a concentration of between 10 to 200 mM, wherein the administration results in:
- promoting wound healing;
- reducing at least one microbe selected from the group consisting of L. casei, C. difficile, P. acnes, C. perfringens, L. casei, E. coli, S. aureus 6538, S. aureus 33591,, S. mutans, S. pyogenes, P. aeruginosa, K. pneumonia, and C. albicans;
- increasing localized IGF-1 expression; and
- reducing localized TGF-E and EGF expression.
34–35. (Cancelled)
- The method of claim 33, wherein the composition is in the form of a(n) liquid, solution, cream, ointment, salve, gel, emulsion, suspension, dispersion, or paste.
- The method of claim 33, wherein the wound is a burn, skin break, bone break, muscle tear, puncture, surgical incision site, microdermabrasion site, skin graft site, a wound associated with diabetes, a bed sore, a pressure sore, or a laceration.
- The method according to claim 33, wherein the composition is administered in ultradeformable liposomes.
- The method of claim 33 wherein the PCA and 246THBA are each present at a concentration between 20 to 100 mM.
- The method of claim 33 wherein the PCA and 246THBA are each present at a concentration between 20-50 mM.
- The method of claim 33 wherein the PCA and 246THBA are each present at a concentration of about 25 mM.
- The method of claim 33 wherein the PCA and 246THBA are each present at a concentration at about 50 mM.
- The method of claim 33 wherein the composition may be administered by any conventional route including, oral, topical, buccal, injection, pulmonary, intravenous, inhalant, subcutaneous, sublingual, or transdermal.
- The method of claim 33 wherein the treating of the wound is a cosmetic method of treating skin to enhance skin healing, wherein the composition is administered topically, orally or by intradermal or subcutaneous injection to a skin tissue, wherein the composition promotes an effect selected from the group consisting of reducing inflammation, optimizing growth hormone production, and increasing collagen stimulation.
45–52. (Cancelled)
- The method according to claim 33, wherein said administration further results in reduced scar formation.
