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My Comments on the Health Care Industry’s CEO’s Innovation Visions

2/16/2018: Alex Gorsky, the CEO of Johnson & Johnson recently made the following statements concerning where healthcare innovation is headed.  Here is what I think about each of his factors listed in bolding. There must be a sense of urgency.  This is rarely seen in health care because they are slow to change their culture or way of doing business.  Why is there no change?  The have been successful in doing what they always have done. This requires us to actually re-imagine Johnson & Johnson as a 132-year-old startup.  The cultural background and personalities of those who came up through this system does not allow them to imagine what it takes to be a start up; personal risk, handling failure, more time than anticipated, and the idea of trying again.                           One that embraces and acts on the best ideas.  This is unlikely to happen since “corporate’s” idea of the best ideas are ones that produce profit in the next quarter, not five years from now when they will be retired or at another company. One that is nimble and fast.  This is unlikely as the junior officers are not going to risk loosing their job by proposing an idea or plan that requires a fast and nimble approach to new products. They know that no one got to the top of “corporate” doing it this way. One that leverages technology to drive life-changing and life-saving innovation.  The risk adverse culture will never leverage as this word contains risk.  Let me give you an example.  There is a US patented way to coat total joint implants at the time of surgery to prevent attachment of biofilm bacterial colonies.  The major orthopedic industry will not take this on because of the estimate of 10 years and 50-150 million dollars to get through the FDA.  They cannot even entertain a known less expensive way in time and money to get there. One that focuses on being competitive always.  Being competitive means you are the fittest and fastest with the most mental toughness.  High profits inherent in the major medical companies never have required these characteristics and will not, because it has not been necessary to date for success. One that embraces transformative products.  The corporate mentality of the “Big Pharma” has ignored the nutraceutical industry which incidentally is growing very fast., One that has quality services.  This factor does exist with present managements, marketing, sales and distribution. One that has transparent pricing.  This is not likely as the R&D and cost of doing business is so high, it requires new blockbuster drugs for cancer to sell for up to $100,000 per patient treatment; yes $100,000.   This is not you new aspirin. One that has all the factors with the consumer top-of-mind.  If this was so it would not have been almost 30 years since introduction of a new antibiotic.  Why is this?  The cost to develop plus regulations would not allow the same profit margin as cancer or arthritis. Summary Insights: For safety, medical companies usually do acquisitions, not innovations.  After all they are in the business of making money.

Real Feel Gloves launch

2/9/2018: The Real Feel Glove initiative was launched at the PGA show in Orlando.  Web site is up at  The interesting aspect is the suggestions to so many performance enhancing applications; golf, basketball, football, sport shooting as in Olympics, fly fishing and even musical instruments. Presently doing testing on PGA tour for supporting evidence.  US patent has been granted.

You may not be the first to make a discovery

1/7/2018:  You may not be the first to make a discovery.  I loved this short video’s teaching moment.

High Cost of Drugs; Why?

4/27/17: Drugs are expensive for one main reason; cost of FDA regulations.  New drug submissions require a Phase I to show they are safe.  Then a Phase II of 500-1000 cases to show it works.  If still positive then a Phase III of 2000 to 10000 cases are required with at least a 2 year follow-up. Here are the facts.  Only 15% of drugs are approved.   85% fail, but unfortunately they fail in Phase III when the millions are spent.  So the drug companies must cover the cost of the 85% that fail in the charge for the 15% that pass. Cases in point: I have a patented means to reduce surgical infections by coating a total joint implant at time of surgery so that any bacteria or biofilm colony would be destroyed upon contact.   No total joint company is interested in that the cost of the FDA study would be 50 to 150 million dollars to attempt to gain approval.  There would be a humanitarian and societal benefit, but the companies are in business to make money. It was announced today that back in 2014, Roche spent $725 million upfront on Seragon Pharmaceuticals, but three years down the line, it has now canned work on its leading drug, ARN-810.  

Another Patent Granted

12/11/2016: US patent was granted. 9,498,413  Anti-microbials and methods of use thereof for would healing. November 22, 2016 This established that protocatechuic acid is a broad spectrum antibiotic.  I also secured this same reagent as one that promotes rapid wound healing. The application included 32 claims, but the US patent office only will review two or three at at time.  This makes their work easiler and the applicant has to pay again for each subsequent review.  I have been told, the US patent office is the only division of the Federal Government that makes money. So we will return to secure other claims for which we have scientific evidence; biofilm destroying reagent to coat implants and reduce infection; spray disinfectan, creams and soaps for killing bacteria on skin; i.e. Acne. The next hurdle is the regulations with the FDA and EPA before we could go to market. Good thing I am young.

US Patent Issued after Saga

11/23/2016: US patent was issued after a multi year saga.  The research started more than 10 years ago and resulted in certain claims being granted in 2012.  However the patent office examiner did not allow all claims, specifically the direct intra articular injection of these dyes that are found in plants.  So more time and money was spent and now the issue is settled. US 9, 486, 468 B2 was issued November 8, 2016 granting claims stating that intra articular of anthocyanins and or anthocyanidins to stimulate the synovium (joint lining) to make a growth hormone; IGF-1.  The result there in will improve the nutrition and protect the cartilage in the joint and potentially heal the arthritic joint. The sage is not over yet in that subsequent research showed that the active ingredient is the primary metabolite of those dyes; protocatechuic acid (PCA).  I now have supporting research to expand the claims to include the injection of PCA.  So back to the patent office with more money and time. These are just the first of many hurdles, as I now face the FDA reglations before available for marketing.

Regulators Gone Wild

9/29/2016: Regulators gone wild.  I was with a famous orthopedic researcher today for lunch.  He is head of orthopedic research at two of America’s most prestigious universities.   Now listen to this.  He has a grant funded to study spinal cord injuries that will start soon, so there is no money available presently.  He wanted to study the rat’s spinal cord anatomy so that when the project starts, he will know exactly the approach and technique to this heretofore unexplored anatomy.   So he asked around the laboratory for any dead rats.  None were available.  So with his own money he purchased some rats and humanely euthanized them.  He then dissected the spine and spinal cord to see how best to perform their up coming research.   The regulators at his institution learned of this and called him in for an explanation.  He had violated the regulations by not registering his use of the rats, especially killing them.   He received a 6 week “sanction” and cessation from research activities as the punishment.   Rats are killed every day in every city in America.  It is legal.  Home Depot sells the poisons and traps.  People spend their own money to do this with no research in mind.  This is legal.  No reprisals and no regulators.